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Tabella  sui risultati terapeutici realizzati dall’utilizzo di

cellule staminali adulte e cordonali

Trattasi di una tabella esclusivamente esemplificativa dei risultati degli studi sulle cellule staminali adulte. Si precisa, infatti, che essa non ha alcuna pretesa di essere esaustiva sull’argomento trattato, avendo peraltro ad oggetto studi e ricerche in continua evoluzione. Sono stati riportati in tale sede solo alcuni di questi recentissimi risultati che confermano la competitività epigenetica delle cellule staminali da tessuti di adulto (ASC) rispetto a quelle embrionali (ES) e la loro valida candidatura per la terapia cellulare (trapianti autologhi ed eterologhi) e la terapia genica somatica.

 

 

LESIONI E TRAUMA

 

1. GANGRENA DEGLI ARTI (LIMB GANGRENE)
Tateishi-Yuyama E et al.; “Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial”; Lancet 360, 427-435; 10 August 2002.

2. TRATTAMENTO FERITE CUTANEE
Badiavas EV, “Participation of Bone Marrow Derived Cells in Cutaneous Wound Healing”, Journal Of Cellular Physiology 196, 245-250; 2003.

3. RICOSTITUZIONE DELLA MASCELLA (JAWBONE REPLACEMENT)
Warnke PH et al., Growth and transplantation of a custom vascularised bone graft in a man, Lancet 364, 766-770, 28 August 2004

4.
RICOSTITUZIONE OSSEA (SKULL BONE REPAIR)
Lendeckel S et al., Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report, Journal of Cranio-Maxillofacial Surgery 32, 370-373, 2004

 

CANCRO

 

1.                TUMORI AL CERVELLO (BRAIN TUMORS) - Medulloblastoma and glioma Dunkel, IJ; “High-dose chemotherapy with autologous stem cell rescue for malignant brain tumors”; Cancer Invest. 18, 492-493; 2000. Abrey, LE et al.; “High dose chemotherapy with autologous stem cell rescue in adults with malignant primary brain tumors”; J. Neurooncol. 44, 147-153; Sept., 1999 Finlay, JL; “The role of high-dose chemotherapy and stem cell rescue in the treatment of malignant brain tumors: a reappraisal”; Pediatr. Transplant 3 Suppl. 1, 87-95; 1999

2.                RETINOBLASTOMA
Hertzberg H et al.; “Recurrent disseminated retinoblastoma in a 7-year-old girl treated successfully by high-dose  chemotherapy and CD34-selected autologous peripheral blood stem cell transplantation”; Bone Marrow Transplant 27(6), 653-655; March 2001; Dunkel IJ et al.; “Successful treatment of metastatic retinoblastoma”; Cancer 89, 2117-2121; Nov 15 2000

3.                CANCRO DELLE OVAIE (OVARIAN CANCER)
Stiff PJ et al.; “High-dose chemotherapy and autologous stem-cell transplantation for ovarian cancer: An autologous blood and marrow transplant registry report”; Ann. Intern. Med. 133, 504- 515; Oct. 3, 2000 Schilder, RJ and Shea, TC; “Multiple cycles of high-dose chemotherapy for ovarian cancer”; Semin. Oncol. 25, 349-355; June 1998

4.                CARCINOMA A CELLULE MERKEL (MERKEL CELL CARCINOMA)
Waldmann V et al.; “Transient complete remission of metastasized merkel cell carcinoma by highdose polychemotherapy and autologous peripheral blood stem cell transplantation”; Br. J. Dermatol. 143, 837-839; Oct 2000

5.                CANCRO DEI TESTICOLI (TESTICULAR CANCER)
Bhatia S et al.; “High-dose chemotherapy as initial salvage chemotherapy in patients with relapsed testicular cancer”; J. Clin. Oncol. 18, 3346-3351; Oct. 19, 2000 Hanazawa, K et al.; “Collection of peripheral blood stem cells with granulocyte-colony-stimulatin factor alone in testicular cancer patients”;Int. J. Urol. 7, 77-82; March 2000.

6.                LINFOMA (LYMPHOMA)
Tabata M et al.; “Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma--possibility of early completion of chemotherapy and improvement of performance status”; Intern Med 40, 471-474; June 2001  Josting, A; “Treatment of Primary Progressive Hodgkin’s and Aggressive Non-Hodgkin’s Lymphoma: Is There a Chance for Cure?”; J Clin Oncol 18, 332-339; 2000; Koizumi M et al.; “Successful treatment of intravascular malignant lymphomatosis with high-dose chemotherapy and autologous peripheral blood stem cell  transplantation”;Bone Marrow Transplant 27, 1101-1103; May 2001  

7.                LEUCEMIA LINFOCITICA ACUTA (ACUTE LYMPHOBLASTIC LEUKEMIA)
Ohnuma K et al.; “Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies”; Br J Haematol 112(4), 981-987; March 2001 Marco F et al.; “High Survival Rate in Infant Acute Leukemia Treated With Early High-Dose Chemotherapy and Stem-Cell Support”; J Clin Oncol 18, 3256-3261; Sept. 15 2000 

8.                LEUCEMIA MIELOCITICA ACUTA (ACUTE MYELOGENOUS LEUKEMIA)
Ohnuma K et al.; “Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies”;  Br J Haematol 112(4), 981-987; March 2001Gorin NC et al.; “Feasibility and recent improvement of autologous stem cell transplantation for acute myelocytic  leukaemia in patients over 60 years of age: importance of the source of stem cells”; Br. J. Haematol. 110, 887-893; Sept 2000 Bruserud O et al.; “New strategies in the treatment of acute myelogenous leukemia: mobilization and transplantation of autologous peripheral blood stem cells in adult patients”; Stem Cells 18, 343- 351; 2000

9.                LEUCEMIA MIELOCITICA CRONICA (CHRONIC MYELOGENOUS LEUKEMIA) Ohnuma K et al.; “Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies”; Br J Haematol 112(4), 981-987; March 2001

10.           LEUCEMIA MIELOMONOCITICA INFANTILE (JUVENILE MYELOMONOCYTIC LEUKEMIA)
Ohnuma K et al.; “Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies”; Br J Haematol 112(4), 981-987; March 2001 

11.           LINFADENOPATIA ANGIOIMMUNOBLASTICA CON DISPROTEINEMIA (ANGIOIMMUNOBLASTIC LYMPHADENOPATHY with DYSPROTEINEMIA) Lindahl J et al.; “High-dose chemotherapy and APSCT as a potential cure for relapsing hemolysing AILD”; Leuk Res 25(3), 267-270; March 2001

12.           MIELOMA MULTIPLO (MULTIPLE MYELOMA)
Laughlin MJ et al.; “Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors”,  New England Journal of Medicine 344, 1815-1822; June 14, 2001 Vesole, DH et al.; “High-Dose Melphalan With Autotransplantation for Refractory Multiple Myeloma:  Results of a Southwest Oncology Group Phase II Trial”; J Clin Oncol 17, 2173-2179; July 1999.

13.           MIELODISPLASIA O SINDROME MIELODISPLASTICA (MYELODYSPLASIA)
Ohnuma K et al.; “Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies”;  Br J Haematol 112(4), 981-987; March 2001 Bensinger WI et al.; “Transplantation of bone marrow as compared with peripheral-blood cells from HLAidentical relatives in patients with hematologic cancers”; New England Journal of Medicine 344, 175-181; Jan 18 2001

14.           CANCRO AL SENO (BREAST CANCER)
Damon LE et al.; “High-dose chemotherapy and hematopoietic stem cell rescue for breast cancer: experience in California”;  Biol. Blood Marrow Transplant 6, 496-505; 2000 Paquette, RL et al., “Ex vivo expanded unselected peripheral blood: progenitor cells reduce posttransplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer”, Blood 96, 2385-2390; October, 2000.
Stiff P et al.; “Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose  chemotherapy for breast cancer”; Blood 95, 2169-2174; March 15, 2000 Koc, ON et al.; “Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow  Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy”; J Clin Oncol 18, 307-316; January 2000

15.           NEUROBLASTOMA
Kawa, K et al.; “Long-Term Survivors of Advanced Neuroblastoma With MYCN Amplification: A Report of 19 Patients Surviving  Disease-Free for More Than 66 Months”; J Clin Oncol 17:3216- 3220; October 1999 

16.           LINFOMA NON-HODGKIN (NON-HODGKIN’S LYMPHOMA)
Tabata M et al.; “Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma--possibility of  early completion of chemotherapy and improvement of performance status”; Intern Med 40, 471-474; June 2001 Josting, A; “Treatment of Primary Progressive Hodgkin’s and Aggressive Non-Hodgkin’s Lymphoma: Is There a Chance for Cure?”;  J Clin Oncol 18, 332-339; 2000 Kirita T et al.; “Primary non-Hodgkin’s lymphoma of the mandible treated with radiotherapy, chemotherapy, and autologous peripheral blood stem cell transplantation”; Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90, 450-455; Oct. 2000
Yao M et al.; “Ex vivo expansion of CD34-positive peripheral blood progenitor cells from patients with non-Hodgkin’s lymphoma: no evidence of  concomitant expansion of contaminating bcl2/JHpositive lymphoma cells”; Bone Marrow Transplant 26, 497-503; Sept. 2000

17.           LINFOMA DI HODGKIN (HODGKIN’S LYMPHOMA)
Peggs KS et al., “Clinical evidence of a graft-versus-Hodgkin’s-lymphoma effect after reducedintensity allogeneic transplantion”, Lancet 365, 1934-1941, 4 June 2005 Josting, A; “Treatment of Primary Progressive Hodgkin’s and Aggressive Non-Hodgkin’s Lymphoma: Is There a Chance for Cure?”; J Clin Oncol 18, 332-339; 2000

18.           CARCINOMA RENALE (RENAL CELL CARCINOMA)
Childs R et al., “Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation”, New England Journal of Medicine 343, 750-758; Sept. 14, 2000 Childs, RW; “Successful Treatment of Metastatic Renal Cell Carcinoma With a Nonmyeloablative Allogeneic Peripheral-Blood Progenitor-Cell Transplant: Evidence for a Graft-Versus-Tumor Effect:; J Clin Oncol 17, 2044-2049; July 1999

 

19.           VARI TUMORI SOLIDI (VARIOUS SOLID TUMORS)
Nieboer P et al.; “Long-term haematological recovery following high-dose chemotherapy with autologous bone marrow transplantation or peripheral stem cell transplantation in patients with solid tumours”; Bone Marrow Transplant 27, 959-966; May 2001 Lafay-Cousin L et al.; “High-dose thiotepa and hematopoietic stem cell transplantation in pediatric malignant mesenchymal tumors: a phase II study”; Bone Marrow Transplant 26, 627-632; Sept. 2000 Michon, J and Schleiermacher, G. “Autologous haematopoietic stem cell  transplantation for paediatric solid tumors”, Baillieres Best Practice Research in Clinical Haematology 12, 247-259, March-June, 1999.
Schilder, RJ et al.; “Phase I trial of multiple cycles of high-dose chemotherapy supported by autologous peripheral-blood stem cells”; J. Clin. Oncol. 17, 2198-2207; July 1999

20.           SARCOMA DEI TESSUTI MOLLI (SOFT TISSUE SARCOMA)
Blay JY et al.; “High-dose chemotherapy with autologous hematopoietic stem-cell transplantation for advanced soft tissue sarcoma in adults”; J. Clin. Oncol. 18, 3643-3650; Nov 1 2000

21.           LINFOISTIOCITOSI EMOFAGOCITICA (HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS)
Matthes-Martin S et al.; “Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis”; Blood 96, 3997-3999; Dec 1, 2000

22.           MACROGLOBULINEMIA DI WALDENSTROM (WALDENSTROM’S MACROGLOBULINEMIA)
Anagnostopoulos A et al.; “High-dose chemotherapy followed by stem cell transplantation in patients with resistant Waldenstrom's macroglobulinemia”; Bone Marrow Transplant 27, 1027- 1029; May 2001

 

23.           SINDROME POEMS (POEMS SYNDROME) O MIELOMA OSTEOSCLEROTICO (OSTEOSCLEROTIC MYELOMA)
Dispenzieri A et al., Peripheral blood stem cell transplantation in 16 patients with POEMS syndrome, and a review of the literature, Blood 104, 3400-3407, 15 November 2004

24.           MORBO DI PARKINSONG (PARKINSON’S DISEASE) Lévesque M and Neuman T, “Autologous transplantation of adult human neural stem cells and differentiated dopaminergic neurons for Parkinson disease:  1-year postoperative clinical and functional metabolic result”, American Association of Neurological Surgeons annual meeting, Abstract #702; 8 April 2002 Love S et al., Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain, Nature Medicine 11, 703-704, July 2005 Gill SS et al.; “Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease”; Nature Medicine 9, 589-595; May 2003  (published online 31 March 2003) See also July 14, 2004 Senate testimony by Dr. Michel Lévesque: http://commerce.senate.gov/hearings/testimony.cfm?id=1268&wit_id=3670 and Mr. Dennis Turner:
http://commerce.senate.gov/hearings/testimony.cfm?id=1268&wit_id=3676

 

Anemie

 

1.          ANEMIA A CELLULE FALCIFORMI (SICKLE CELL ANEMIA)
Gore L. et al.; “Successful cord blood transplantation for sickle cell anemia from a sibling who is human leukocyte antigen-identical: implications for comprehensive care”, J Pediatr Hematol Oncol 22(5):437-440; Sep-Oct 2000
Steen RG et al.; “Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts”; Ann Neurol 49(2), 222-229; Feb. 2001
Wethers DL; “Sickle cell disease in childhood: Part II. Diagnosis and treatment of major complications and recent advances in treatment”; Am. Fam. Physician 62, 1309-1314; Sept. 15, 2000

2.   ANEMIA SIDEROBLASTICA (SIDEROBLASTIC ANEMIA)
Ayas M et al.; “Congenital sideroblastic anaemia successfully treated using allogeneic stem cell transplantation”; Br J Haematol 113, 938-939; June 2001
Gonzalez MI et al.; “Allogeneic peripheral stem cell transplantation in a case of hereditary sideroblastic anaemia”; British Journal of Haematology 109, 658-660; 2000

3.   APLASIA SPECIFICA DELLE CELLULE ROSSE (RED CELL APLASIA)
Rabusin M et al.; “Immunoablation followed by autologous hematopoietic stem cell infusion for the treatment of severe autoimmune disease”; Haematologica 85(11 Suppl), 81-85; Nov. 2000

4.   ANEMIA APLASTICA (APLASTIC ANEMIA)
Gurman G et al.; “Allogeneic peripheral blood stem cell transplantation for severe aplastic anemia”; Ther Apher 5(1), 54-57; Feb. 2001
Kook H et al.; “Rubella-associated aplastic anemia treated by syngeneic stem cell transplantations”; Am. J. Hematol. 64, 303-305; August 2000

5.   TROMBOCITOPENIA AMEGACARIOCITICA (AMEGAKARYOCYTIC THROMBOCYTOPENIA)
Yesilipek et al.; “Peripheral stem cell transplantation in a child with amegakaryocytic thrombocytopenia”; Bone Marrow Transplant 26, 571-572; Sept. 2000

6.   VIRUS DI EPSTEIN-BARR (CHRONIC EPSTEIN-BARR INFECTION)
Fujii N et al.; “Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active epstein-barr virus infection”; Bone Marrow Transplant 26, 805-808; Oct. 2000
Okamura T et al.; “Blood stem-cell transplantation for chronic active Epstein-Barr virus with lymphoproliferation”; Lancet 356, 223-224; July 2000

7.   ANEMIA DI FANCONI (FANCONI’S ANEMIA)
Kohli-Kumar M et al., “Haemopoietic stem/progenitor cell transplant in Fanconi anaemia using HLAmatched sibling umbilical cord blood cells”, British Journal of Haematology 85, 419-422, October 1993

8.   ANEMIA DI DIAMOND BLACKFAN (DIAMOND BLACKFAN ANEMIA)
Ostronoff M et al., “Successful nonmyeloablative bone marrow transplantation in a corticosteroidresistant infant with Diamond-Blackfan anemia”, Bone Marrow Transplant. 34, 371-372, August 2004

9
.   TALASSEMIA (THALASSEMIA)
Tan PH et al., “Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major”, Am J Hematol 75, 209-212, April 2004

10.  AMILOIDOSI PRIMARIA (PRIMARY AMYLOIDOSIS)
Sezer O et al.; “Novel approaches to the treatment of primary amyloidosis”; Exper Opin. Investig. Drugs 9, 2343-2350; Oct 2000


OCCHI

1.                RICOSTRUZIONE DELLA CORNEA (CORNEAL REGENERATION)
Nishida K et al., Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium, New England Journal of Medicine 351, 1187-1196, 16 September 2004
Anderson DF et al.; “Amniotic Membrane Transplantation After the Primary Surgical Management of Band Keratopathy”; Cornea 20(4), 354-361; May 2001
Anderson DF et al.; “Amniotic membrane transplantation for partial limbal stem cell deficiency”; Br J Ophthalmol 85(5), 567-575; May 2001
Henderson TR et al.; “The long term outcome of limbal allografts: the search for surviving cells”; Br J Ophthalmol 85(5), 604-609; May 2001
Daya SM, Ilari FA; “Living related conjuctival limbal allograft for the treatment of stem cell deficiency”; Opthalmology 180, 126-133; January 2001
Schwab IR et al.; “Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease”; Cornea 19, 421-426; July 2000.
Tsai et al.; “Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells.”; New England Journal of Medicine 343, 86-93, 2000.
Tsubota K et al.; “Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation”; New England Journal of Medicine 340, 1697-1703;  June 3, 1999 Ocular corneal regeneration

 

ALTRE MALATTIE

 

 

1.     OSTEOGENESI IMPERFETTA (OSTEOGENESIS IMPERFECTA)
Horwitz EM et al., “Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta:  Implications for cell therapy of bone”, Proceedings of the National Academy of Sciences USA 99, 8932-8937; 25 June 2002.
Horwitz EM et al., “Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta”, Blood 97, 1227-1231; 1 March 2001.
Horwitz, EM et al.; “Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta”; Nat. Med. 5, 309-313; March 1999.

2.                OSTEOPETROSI (OSTEOPETROSIS)
Driessen GJ et al., Long-term outcome of haematopoietic stem cell transplantation in autosomal recessive osteopetrosis: an EBMT report, Bone Marrow Transplantation 32, 657-663, October 2003
Schulzetal, HLA-haploidentical blood progenitor cell transplantation in osteopetrosis, Blood 99, 3458- 3460, 1 May 2002

3. ADRENOLEUCODISTROFIA (CEREBRAL X-LINKED ADRENOLEUKODYSTROPHY)
Peters C et al., Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999,  Blood 104, 881-888, 1 August 2004

4.
SINDROME DI SANDHOFF (SANDHOFF DISEASE)
Karen Augé, “Stem cells infuse kin with hope”, Denver Post Tuesday, August 24, 2004

5. SINDROME DI HURLER (HURLER’S SYNDROME)
Staba SL et al., Cord-blood transplants from unrelated donors in patients with Hurler’s syndrome”, New England Journal of Medicine 350, 1960-1969, 6 May 2004
Koc ON et al., Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH), Bone Marrow Transplant 215-222; Aug 2002.

6. MALATTIE DI KRABBE (KRABBE LEUKODYSTROPHY)
Escolar ML et al., “Transplantation of umbilical cord-blood in babies with infantile Krabbe’s disease”, New England Journal of Medicine 352, 2069-2081, 19 May 2005
Krivit W et al., “Hematopoietic Stem-Cell Transplantation in Globoid-Cell Leukodystrophy”, New England Journal of Medicine 338, 1119-1127, Apr 16, 1998 

 

 

ALCUNE PATOLOGIE CARDIACHE

 

 

 

Wollert KC et al., “Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial”, Lancet 364, 141-148, 10 July 2004 Britten MB et al., “Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction”; Circulation 108, 2212-2218; Nov 2003 Perin EC et al.; “Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure”; Circulation 107, r75-r83; published online May 2003 Stamm C et al.; “Autologous bone-marrow stem-cell transplantation for myocardial regeneration”; The Lancet 361, 45-46; 4 January 2003 Tse H-F et al.; “Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation”; The Lancet 361, 47-49; 4 January 2003 Strauer BE et al.; “Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans”; Circulation 106, 1913-1918; 8 October 2002 Strauer BE et al.; “Myocardial regeneration after intracoronary transplantation of human autologous stem cells following acute myocardial infarction”;Dtsch Med Wochenschr 126, 932- 938; Aug 24, 2001 Menasché P et al. “Myoblast transplantation for heart failure.” Lancet 357, 279-280; Jan 27, 2001 Menasché P et al. [“Autologous skeletal myoblast transplantation for cardiac insufficiency. First clinical case.”] [article in French] Arch Mal Coeur Vaiss 94(3), 180-182; March 2001

     

 

Istituto per lo studio e la cura del diabete - Centro di diabetologia accreditato SSN
Regione Campania - Centro di Ricerca sul Piede Diabetico e sull'Educazione Alimentare
decreto n.315 del 19-12-2004
Via XXV aprile, complesso Ex Abetaia - Casagiove - 81022
 
ultimo aggiornamento domenica 27 giugno 2010 12.48.49
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